The results of several studies have questioned the use of polyglactin for guided tissue regeneration (GTR) procedures, reporting that the mesh provides an insufficient barrier because of fragmentation of the material. (MedCrave)

A barrier membrane is a device originally used to prevent epithelial migration into a specific area in the guided tissue regeneration (GTR) procedure. (ScienceDirect)

In case of periapical lesions, guided tissue regeneration (GTR) is attempted to improve the self-regenerative healing process by excluding undesired proliferation of the gingival connective tissue or migration of the oral epithelial cells into osseous defects. (SciELO)